Upcoming relevant seminars for the IBSC, Department of Molecular, Cell and Developmental Biology, Baskin School of Engineering, and other relevant events are listed here.
Have a relevant upcoming event? Contact the IBSC and we will post your event to this page.
Pinned MCD Seminar
Intersectional Environmentalism: The key to Fighting Racism and Climate Change Through a Lens of Science and Community Building
Tuesday, November 15th - 12:00pm - METX Seminar Series
Meeting ID: 917 8448 7738
Laura Cook, Binghamton University - "Mucosal colonization by pathogenic streptococci"
Laura has been an Assistant Professor at Binghamton University since the Fall of 2018. Her postdoctoral studies focused on quorum sensing in streptococci and the role of cell-cell signaling in colonization of the host. Projects like this have influenced the work currently done in her lab.
Tuesday, November 15th - 7:00pm - UCI Sue & Bill Gross Stem Cell Research Center Hybrid Community Lecture
Register for the webinar here
(1) Ed Monuki, M.D., Ph.D.
(2) Albert La Spada, M.D., Ph.D.
"Did You Know Your Brain Floats? Molecules, Cells, and Fluids That Create a Healthy Brainyard Pool"
About the Speakers
Ed Monuki - After growing up in Los Angeles, Dr. Monuki received his BS from MIT, then his MD and PhD degrees from UC San Diego. As a PhD student, he worked on developing glial cells with Greg Lemke at the Salk Institute. He then moved to Boston for residency and fellowship training in Anatomic Pathology and Neuropathology. While attending at the Brigham & Women’s Hospital and Boston Children’s Hospital, he carried out postdoctoral research on the developing forebrain with Chris Walsh at the Beth Israel Deaconess Medical Center before joining UCI in 2001.
Albert La Spada - Dr. La Spada graduated Summa Cum Laude from the University of Pennsylvania with a degree in Biology in 1986. As a M.D. - Ph.D. student at the University of Pennsylvania School of Medicine, he identified the cause of X-linked spinal & bulbar muscular atrophy (SBMA) as an expansion of a trinucleotide repeat in the androgen receptor gene. As the first disorder shown to be caused by an expanded repeat tract, this discovery of a novel type of genetic mutation led to the emergence of a new field of study.
Thursday, December 1st - 12:00pm - BSOE Dissertation Defense
Thursday, December 1, 2022 - 12:00pm
Location: PSB 305 and Zoom - https://ucsc.zoom.us/j/98347094038?pwd=WGZvUUVlbm9MaE91NEd3MkZDZ1ZWZz09; Passcode: 628845
Lucas Seninge, PhD Candidate, Biomolecular Engineering & Bioinformatics; Advisor: Joshua Stuart
Abstract: Single-cell RNA sequencing (scRNA-Seq) has offered a unique window into studying cellular identity at unprecedented scale and resolution. However, the process of revealing this cellular identity remains challenging. For example, the annotation of each assayed cell with a cell type label indicating its functional identity still relies on manual examination, which is rate-limiting and poses reproducibility issues. Similarly, inferring the activity of gene regulatory pathways specifying cell state relies on methods designed for bulk RNA sequencing data and do not make use of the important amount of data generated by single-cell experiments. Here, I describe my work to combine prior biological knowledge about cellular entities contained in curated databases and machine learning to shed light on the cellular identity of single cells.
Specifically, I developed statistical frameworks for the automated annotation of single-cell transcriptomes with cell type labels by integrating prior cell ontology information and cell type-specific marker gene sets. Then, I developed a method to infer pathway activity in single cells by using recent progress in the field of deep generative modeling as well as prior knowledge from gene annotation databases. I discuss potential future direction to design generative model architectures to approach the more ambitious task of modeling targeted perturbation of pathways or transcription factors to perform in-silico experiments and alter cellular state at the single-cell level. This body of work contributes to the growing literature of methods incorporating prior knowledge about biological systems into complex machine learning frameworks, as well as highlights the challenges met in such integration.
Thursday, November 10th - 4:00pm - RNA Club Speaker Series
Sinsheimer Building, Room 123, 4:00PM
(1) Michael Lawson, Puglisi Lab, Stanford - “Basis of Speed and Fidelity in Eukaryotic Translation Termination"
(2) Nicole Martinez, Martinez Lab, Stanford - "Uncovering new functions of RNA modifications in mRNA processing”
Tuesday, November 8th - 3:30pm - Neuroclub Neuroscience Speaker Series
Physical Sciences Building, Room 240, 3:30 - 5:00PM
(1) Anna Gillespie, Ph.D., Frank lab; UCSF - “A novel approach to modulating hippocampal memory replay”
(2) Max Turner, Ph.D., Clandinin lab; Stanford - “Self motion signals dynamically shape a population code for visual feature detection in Drosophila”
About the Speakers
Anna Gillespie hails from Loren Frank's lab at UCSF, where she is currently finishing up her post-doc work, however we have the distinct pleasure of hosting Anna just before she starts her own lab at University of Washington. She is actively recruiting graduate students, post-docs, and technicians, so please encourage your lab members and students to connect with her if they are interested in any of those positions. Her talk is entitled, "A novel approach to modulating hippocampal memory replay".
Max Turner comes to us from Thomas Clandinin's lab at Stanford University. He will be presenting a talk titled "Self motion signals dynamically shape a population code for visual feature detection in Drosophila" which will feature data primarily from this preprint perhaps with some new data from recent months added in.
Thursday, October 27th - 12:00pm - Chromatin Club Bay Area
(1) Bradley Colquitt, Assistant Professor MCD
"Gene Regulatory Mechanisms of Birdsong Neural Circuit Development"
(2) Albert Li - Jiangbin Ye Lab, Stanford University
"Metabolic and Epigenetic Reprogramming During Breast Cancer Progression"
(3) TBD - UC Davis
Presentation Title TBD
Wednesday, October 26th - 1:00pm - In Vivo Imaging Of Human Neuronal Development At Single Cell Resolution In Chimera Models
In Vivo Imaging Of Human Neuronal Development At Single Cell Resolution In Chimera Models
Yi Zuo, Ph.D., UCSC; Krishnan Padmananbhan, Ph.D.
When: Wednesday, Oct 26, 1:05 PM, Biomed200
While the structural changes that human neurons undergo during development are key to understanding neural circuit function, there are currently limited ways to study these dynamic processes. To address this challenge, we developed a novel method for time-lapse in vivo two-photon imaging of GFP-labeled human neural precursor cells (hNPCs) derived from induced Pluripotent Stem Cells (iPSCs) transplanted into the visual cortex of a mouse. By imaging over both short periods (~1 hour) and long intervals (~1 week), we were able to uncover features of hNPC proliferation, migration and growth dynamics across different times scales of development for up to 8 months. In transplants with large numbers of engrafted hNPCs, we observed extensive cell proliferation and migration. Migrating cells tended to travel towards and accumulate around blood vessels, with neurites surrounding and ultimately ensheathing these vessels. By contrast, in transplants with small numbers of engrafted hNPCs, we could identify individual neurites that were tracked for up to 8 months. In these engrafts, we observed extensions and retractions of neurites, often as great as 100s of um within a 24-hour period. Furthermore, neurites tended to form fascicles, with extensions favoring the direction of established neurites, suggesting that cells that extend together, stabilize together. Interestingly, these processes often grew along blood vessels, suggesting that the host vasculature plays a critical role in guiding development, possibly as an energy source to supporting both migration and neurite maturation. Taken together, our data allowed us to track the diversity of developmental programs, including proliferation, migration, and neurite maturation from the hNPC state to putative cortical neurons. Our new method thus provides a platform for modeling both normal human development as well as modeling developmental and psychiatric disorders.
Monday, October 24th - 12:00pm - Intersectional Environmentalism: The key to Fighting Racism and Climate Change Through a Lens of Science and Community Building
In Vivo Imaging Of Human Neuronal Development At Single Intersectional Environmentalism: The key to Fighting Racism and Climate Change Through a Lens of Science and Community Building
Emily Pinckney, Marine Biologist, Science Equity advocate, Diversity, Equity, and Inclusion Strategist, Policy Analyst, Intersectional Environmentalist Thought Leader
When: Wednesday, Oct 26, 1:05 PM, Nat Sci Annex 101 + Zoom
Friday, October 21st - 12:00pm - Cell-type-specific roles of androgen receptor in prostate homeostasis and cancer
Cell-type-specific roles of androgen receptor in prostate homeostasis and cancer
Zhu Wang, Department of MCD Biology, UC Santa Cruz
When: Friday, Oct 21, 12-1:05 PM, Nat Sci Annex 101 & Zoom
Meeting ID: 942 2343 0506
Tuesday, October 18th - 7:00pm - Intellectual Property Wars: The Battle for Access to medicines
Friday, October 14th - 12:00pm - Genetic insights into quality control of gene expression
Genetic insights into quality control of gene expression
Joshua Arribere, Ph.D., Assistant Professor of MCD Biology, UC Santa Cruz
When: Friday, Oct 14, 12-1:05 PM, Nat Sci Annex & Zoom
Meeting ID: 954 3087 4685
Monday, October 10th - 12:00pm - Cell Cycle Dynamics that Ensure Genome Stability
Cell Cycle Dynamics that Ensure Genome Stability
Jeanette Gowen Cook, Ph.D.
Professor and Chair, Department of Biochemistry & Biophysics, UNC School of Medicine, Professor, Department of Pharmacology
Member, Lineberger Comprehensive Cancer Center
When: Monday, Oct 10, 12-1:05 PM, Nat Sci Annex & Zoom
Host: Doug Kellogg
Meeting ID: 977 2416 9680