Considering applying to one of the IBSC’s programs? Interested in the research conducted by current trainees? Learn more about each of our current trainees, their research, and their training program below.
2024 IBSC Trainees
Ben Topacio
IRACDA Postdoc
Mentor: Ali Shariati
Project: Elucidating the dynamics and regulation of MAPK signaling during differentiation of pluripotent cells
Ben studies how protein kinases regulate the cell cycle and cell fate decisions of stem cells.
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Bryce Manso
IRACDA Postdoc
Mentor: Camilla Forsberg
Project: Determining how inflammation controls age-specific platelet production by hematopoietic stem cells
Under the overarching study of hematopoietic stem cells and hematopoiesis throughout life, Bryce is studying the role of aging in blood cell production in mice and humans.
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Jess Sevetson
IRACDA Postdoc
Mentor: Sofie Salama
Project Title: Advancing stem cell based organoid models of brain development
Utilizing cerebral organoids, Jess studies how inputs into a neural system affect the activity within that system.
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Kelsie Rodriguez
IRACDA Postdoc
Mentor: Seth Rubin
Project Title: Function and regulation of Cyclin Dependent Kinase 2 (CDK2) in differentiating human embryonic stem cells
Kelsie is currently working on research focused on understanding the mechanism of CDK2/cyclin assembly inhibitors.
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Alison Mills
IRACDA Postdoc
Mentor: William Sullivan
Project Title: Response and Adaptations of Stem Cell Divisions to Catastrophic Genomic Damage
Alison is investigating how ultrafine DNA threads that connect sister and non-sister chromatids during anaphase help preserve genomic integrity by promoting the retention of broken chromosome fragments.
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Cristina Flores
IRACDA Postdoc
Mentor: Susan Carpenter
Project Title: Functional characterization of long noncoding RNAs required for macrophage viability
Cristina’s research focuses on the functional characterization of lncRNAs involved in the viability of macrophages.
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Richard Dickson
IRACDA Postdoc
Mentor: Euiseok Kim
Project: The developmental origins of the neuronal circuits for higher brain functions
Richard investigates the wiring differences between feedback and feedforward neurons in the higher visual areas of the cortex. Determining the developemntal origin of these neurons.
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Kevin Singewald
IRACDA Postdoc
Mentor: Glenn Millhauser
Project: Understanding of native prion protein structure autoregulation of inherent toxicity.
Researching prions, which are involved in neurodegenerative diseases; Kevin’s goal is to use EPR to understand dynamical and structural features of the prion protein.
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Ale Rodrieguez y Baena
IRACDA Postdoc
Mentor: Camilla Forsberg
Project: Determining the molecular regulators of age-specific megakaryopoiesis
Ale aims to determine the role of Nupr1 as a potential regulator of age-specific megakaryopoiesis; and to identify functional drivers of the age-specific megakaryopoiesis pathway by high-throughput CRISPRi screen.
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Estefania Vasquez
IRACDA Postdoc
Mentor: Ali Shariati
Project: Determining molecular mechanisms linking endoreplication and differentiation in trophoblast stem cells
Estefania aims to determine the dynamics of activity and substrate network of CDK2 during TSCs endoreplication; and perform functional analysis of CDK2 substrates during TGCs development.
Anjali Misra
IRACDA Postdoc
Mentor: Upasna Sharma
Project: Investigating the molecular and biochemical function of putative methyltransferase Mettl7a1 in mouse embryonic stem cells
Anjali aims to examine the function of Mettl7a1 in embryonic stem cells and embryos; and examine methyltransferase activity and target RNAs of Mettl7a1.
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Maryam Moarefian
IRACDA Postdoc
Mentor: Upasna Sharma
Project: Understanding the link between neurotransmitter regulation and neurodevelopmental disorders
Maryam aims to adapt an electro-taxis-on-a-chip (ETOC) 2D platform for the development of a 2D microfluidics platform to study polarization, migration directionality, and velocity of single axons; to develop a 3D platform for establishing neural circuitry from MGE to Cortex; and to develop the BEC platform to investigate the effect of excitatory and inhibitory neurotransmitter inputs and iontophoretic calcium disruption.
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Alka Gupta
CIRM Postdoc
Mentor: Upasna Sharma
Project: Soma germline crosstalk for small RNA mediated transgenerational inheritance of paternal environmental conditions.
Alka works to decipher the mechanism of soma-germline communication via the small RNA, potentially carried by the extra cellular vesicles of epididymis known as epididymosomes. Alka also works to understand the effect of external/environmental stress on modulating sperm small RNA payload.
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Sreelakshmi Maroli
CIRM Predoc (Ph.D. Student)
Mentor: Daniel Kim
Project: Transposable element regulation and function in human pluripotent stem cells.
Sree’s research focuses on influence of KRAS on transposable elements in induced pluripotent stem cells.
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Ryan Hoffman
CIRM Predoc (Ph.D. Student)
Mentor: Sofie Salama
Project: The patterning role of the choroid plexus in human cerebral cortex development.
Ryan is developing an organoid model for understanding the composition of embryonic cerebrospinal fluid and the role the choroid plexus (the structure of the brain that generates cerebrospinal fluid) may have on the developmental patterning of the cerebral cortex. In particular, how the serotonin receptor HTR2C contributes to the function of the choroid plexus.
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Taylorlyn Stephan
CIRM Predoc (Ph.D. Student)
Mentor: Ed Green
Project: To study the genetic differences between modern humans and archaic hominins in vitro.
To better understand the evolution of human-specific neural phenotypes, Taylorlyn uses CRISPR in human iPSCs to revert neural genes that are fixed in all modern humans to the ancestral alleles, i.e. shared by Neanderthals, Denisovans and non-human primates.
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Gabby Servito
CIRM Predoc (Ph.D. Student)
Mentor: Bin Chen
Project: Determining the Function of Vangl2 in Stem Cells and Differentiating Neurons in the Cerebral Cortex.
Gabby is focused on how Vangl2, a planar cell polarity protein, is involved in neural stem cell proliferation and cell fate specification in the cerebral cortex.
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Jenna Myers
CIRM Predoc (Ph.D. Student)
Mentor: Camilla Forsberg
Project: Rebalancing megakaryocyte/erythroid fate decisions from aged hematopoietic stem cells (HSCs)
Jenna’s lab’s research recently discovered a direct differentiation pathway from HSCs to MkPs only in aged mice. To generate MkPs in young/middle aged mice, cells go through multiple intermediate progenitors first. Jenna’s research is focused on identifying what genetic differences lie between these two pathways, and if they can be manipulated to direct (or redirect) cell fate.
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Rachel Kerslake
CIRM Postdoc
Mentor: Shaheen Sikandar
Project: Molecular regulators of epithelial stem cells.
Rachel works to determine the role of the adaptor protein GULP1 in breast cancer stem cells at various developmental stages using knock-out mice and organoid approaches.
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Yohei Rosen
CIRM Postdoc
Mentor: David Haussler
Project: New cell culture and observation methods for complex models of normal and ischemic tissue.
Yohei is working on technologies to more accurately model the physical-chemical microenvironment of stem cell based organoid models, in particular aiming at improving cancer and ischemia models.
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Lida Langroudi
CIRM Postdoc
Mentor: Ali Shariati
Project: Decoding spatial subcellular MAPK signaling during differentiation of pluripotent stem cells
Lida aims to determine subcellular substrate specificity of MAPK using proximity labeling; and determine the role of endosomal MAPK in self-renewal and differentiation of mouse embryonic stem cells.
Marcel Rommel
CIRM Postdoc
Mentor: Camilla Forsberg
Project: Controlling HSC Self Renewal by the Epigenetic Landscape
Marcel aims to identify factors affecting the self renewal potential of drHSCs after transplantation; and to identify functional drivers of drHSC self renewal by epigenetic landscape manipulation.
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Yanzhen Nie
CIRM Postdoc
Mentor: Bin Chen
Project: SATB2-associated syndrome
Yanzhen aims to generate mice with LOF and GOF SAS mutations to reveal consequences of SAS mutations on brain development; and to subsequently determine the impacts of increasing wild-type Satb2 expression in cortical projection neurons in Satb2+/- mice on brain development.
Shally Saini
CIRM Predoc (Ph.D. Student)
Mentor: David Boyd
Project: Lung fibroblast subpopulation impact on the quality of tissue repair following influenza virus infection
Shally aims to determine whether distinct lung fibroblast lineages differentially regulate alveolar epithelial stem cell proliferation and differentiation at homeostasis; and determine how activation of distinct fibroblast lineages following influenza A virus (IAV) infection affects epithelial stem cell proliferation and differentiation.
Diksha Sharma
CIRM Predoc (Ph.D. Student)
Mentor: Carrie Partch
Project: Targeting a circadian transcription factor to limit proliferation of glioblastoma cancer stem cells
Diksha will aim to identify small-molecule ligands for allosteric regulation of CLOCK:BMAL1 in GSCs.
Isobel Fetter
CIRM Predoc (Ph.D. Student)
Mentor: Shaheen Sikandar
Project: Identification of novel markers o9f metastasis-initiating cells (MICs)
Isobel aims to investigate the role of LMO2-mediated DNA repair in acquiring stem-like plasticity in breast cancer; and to determine the effect of DNA repair pathways on breast cancer stem cells.
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Julien Menendez
T32 Postdoc
Mentor: Lindsay Hinck
Project: Investigating the role of Notch1 in the DNA damage response and endoreplication of mammary alveolar progenitors
Julien is investigating the role of the transmembrane receptor ROBO2 in regulating mammary alveolar progenitor cell differentiation during pregnancy and lactation.
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Brian Mullen
T32 Postdoc
Mentor: David Feldheim
Project: Determination of brainstem and cortical input contribution to the functional properties of auditory neurons in the mouse SC.
Brian is investigating circuit dynamics involved in auditory processing, utilizing the mouse superior colliculus as a model of how sensory information is processed and integrated.
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Saran Chattopadhyaya
T32 Postdoc
Mentor: Camilla Forsberg
Project: Cause and Consequence of Increased Expansion Capacity of Age-Specific Megakaryocyte Progenitors (MkPs.
Saran’s current study is investigating the cause and consequences of expansion capacity of age specific megakaryocyte progenitors by using a murine model.
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Lyna Kabbani
T32 Postdoc
Mentor: Jeremy Sanford
Project: I3 acts as a post-transcriptional amplifier of MLL-Af4-driven leukemogenic gene expression
Lyna aims to uncover the molecular basis of I3 regulated target selection by RISC; and how I3 modulates RISC-mRNA binding and function in-vivo.
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Tommy Finn
T32 Postdoc
Mentor: Bin Chen
Project: Satb2 recruits several chromatin remodeling complexes, with distinct functions, to effect epigenetic changes in relation to neuronal fate specification
Tommy aims to identify direct targets of Satb2 and the function of Satb2 regulation of promoter-enhancer interaction; and to identify the chromatin remodeling complexes which Satb2 recruits to regulate chromatin landscape and accessibility.
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